Integrative analysis of transcriptomic and metabolomic profiles reveals enhanced arginine metabolism in androgen-independent prostate cancer cells
Abstract Background Prostate cancer is a common solid tumor that affects a significant number of men worldwide.Conventional androgen deprivation therapy (ADT) increases the risk of developing castration-resistant prostate cancer (CRPC).Effective clinical management of patients with CRPC is challenging due to the limited understanding.Methods In thi