INTEGRATIVE ANALYSIS OF TRANSCRIPTOMIC AND METABOLOMIC PROFILES REVEALS ENHANCED ARGININE METABOLISM IN ANDROGEN-INDEPENDENT PROSTATE CANCER CELLS

Integrative analysis of transcriptomic and metabolomic profiles reveals enhanced arginine metabolism in androgen-independent prostate cancer cells

Abstract Background Prostate cancer is a common solid tumor that affects a significant number of men worldwide.Conventional androgen deprivation therapy (ADT) increases the risk of developing castration-resistant prostate cancer (CRPC).Effective clinical management of patients with CRPC is challenging due to the limited understanding.Methods In thi

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Negotiating cultural and legal demands in child protection cases: Experiences and lessons from Ghanaian social workers

Within the context of globalization, social workers need to ensure that international-level professional knowledge and practice do not lead to the oppression of the local people that the profession seeks to serve.One of the challenges for social workers is how to negotiate the sometimes-competing definitions and demands of local and cultural norms

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GIANT CELL TUMOR OF THORACIC SPINE. A CLINICAL CASE OF EFFICIENT RADICAL SPONDYLECTOMY OF THREE VERTEBRAL BODIES

We present a clinical case of Little Boys Flannel surgery performed for giant cell tumor of thoracic spine.This surgery was aimed to perform total en-bloc spondylectomy for three vertebral bodies invaded by tumor to follow principles of radicality and prevent local recurrence.We applied complex multidisciplinary approach when a team of thoracic sur

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